Rank: ~600 Points
Against ALL RACES my opening is:
17 Queen (Build another immediately after this one finishes)
20 Roach Warren
24 2nd Hatch in Main (When Hatch is ~50%, Lair)
Expand when Lair is complete.
Constant Queen/Drone Production until I have about 8-10. Build enough Roaches to defend any early scouted aggression. Beyond this, spread creep, and build whatever does best against your opponents unit composition.
I use this opening because:
I feel the usefulness of Queens throughout the game (especially early game) is extremely underestimated, and I choose to take advantage of the excellent unit Blizzard gave us. Queens are excellent anti-air, and are great support for your ground army when defending. Transfuse and Creep Tumors are grossly underused, in my opinion, and Queens can prove to be excellent defense against Reapers, Hellions, and other harrass units.
Although your expansion is later than normal, you still have excellent production capabilities due to your extra Hatch in Main, and you can produce as many drones as you could if you were to Fast Expand, but you are significantly less vulnerable to early aggression.
Having so many Queens allows you to literally have half of the map covered in creep within 10 minutes, and obviously spreading creep is extremely valuable as it provides vision of your opponents movement and excellent mobility.
Also, 8 Queens with full energy essentially provides a 3200 HP buffer to your defending army, with their transfuse ability (assuming good micro).
I've only recently adopted this strategy, but in the last 50 ladder games I've played, using this build, I've only lost 13, and I attribute those losses to my own faults (including some things seen below in "key things").
Key things for executing this build:
Be extremely diligent in your scouting. At all times, you should know where your enemy is, what units he has, etc. Queens are great GtG support, but if they're the only thing you have, good luck winning.
Once you have a good defense and your natural expansion is fortified, spread more creep and expand like crazy.
Be on top of Spawn Larva!!!! There is no point to having so many Queens if you're not using their production ability!!!!
Replays:ZvP 1ZvP 2ZvT 1ZvT 2ZvZ 1ZvZ 2
I would also like to say that although I may not be among the pros, I believe this overall strategy has great potential, and I would simply like my idea looked at by top players. I would hope people give this idea a chance (because it has been working for me, excellently) and not just blow it off because I'm only Mid-Diamond.